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1

Studies Related to the Carbohydrate Sectors of Esperamicin and Calicheamicin: Definition of the Stability Limits of the Esperamicin Domain and Fashioning of a Glycosyl Donor from the Calicheamicin Domain

Halcomb, Randall L., Boyer, Serge H., Wittman, Mark D., Olson, Steven H., Denhart, Derek J., Liu, Kevin K. C., Danishefsky, Samuel J.

Journal:

Journal of the American Chemical Society

Year:

1995

Language:

english

File:

PDF, 4.02 MB

english, 1995

2

ChemInform Abstract: Stereospecific Synthesis of 7-Deoxy-6-hydroxy Paclitaxel.

Mark D. Wittman, Thomas J. Alstadt, John F. Kadow, Dolatrai M. Vyas, Kathy Johnson, Craig Fairchild, Byron Long

Journal:

Year:

1999

File:

PDF, 24 KB

1999

3

ChemInform Abstract: Synthesis and Antitumor Activity of Novel Paclitaxel—Chlorambucil Hybrids.

Mark D. Wittman, John F. Kadow, Dolatrai M. Vyas, Francis L. Lee, William C. Rose, Byron H. Long, Craig Fairchild, Kathy Johnston

Journal:

Year:

2001

File:

PDF, 28 KB

2001

4

ChemInform Abstract: Synthesis of Metabolically Blocked Paclitaxel Analogues.

Mark D. Wittman, et al. et al.

Journal:

Year:

2001

File:

PDF, 35 KB

2001

5

ChemInform Abstract: Synthesis and Antitumor Activity of Novel C-7 Paclitaxel Ethers (I): Discovery of BMS-184476 (Ia).

Mark D. Wittman, et al. et al.

Journal:

Year:

2002

File:

PDF, 28 KB

2002

6

Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase

Mark D. Wittman, Balu Balasubramanian, Karen Stoffan, Upender Velaparthi, Pieying Liu, Subramaniam Krishnanathan, Joan Carboni, Aixin Li, Ann Greer, Ricardo Attar, Marco Gottardis, Chiehying Chang, Br

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 198 KB

english, 2007

7

SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors

Kurt Zimmermann, Mark D. Wittman, Mark G. Saulnier, Upender Velaparthi, Xiaopeng Sang, David B. Frennesson, Charles Struzynski, Steven P. Seitz, Liqi He, Joan M. Carboni, Aixin Li, Ann F. Greer, Marco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.01 MB

english, 2010

8

The synthesis and biological activity of enediyne minor groove binding hybrids

Mark D. Wittman, John F. Kadow, David R. Langley, Dolatrai M. Vyas, William C. Rose, Wyle Solomon, Nada Zein

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 173 KB

english, 1995

9

Challenges in the development of mGluR5 positive allosteric modulators: The discovery of CPPHA

Zhijian Zhao, David D. Wisnoski, Julie A. O’Brien, Wei Lemaire, David L. Williams Jr., Marlene A. Jacobson, Marion Wittman, Sookhee N. Ha, Herve Schaffhauser, Cyrille Sur, Doug J. Pettibone, Mark E. D

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 192 KB

english, 2007

10

Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)

Upender Velaparthi, Mark Wittman, Peiying Liu, Karen Stoffan, Kurt Zimmermann, Xiaopeng Sang, Joan Carboni, Aixin Li, Ricardo Attar, Marco Gottardis, Ann Greer, ChiehYing Y. Chang, Bruce L. Jacobsen,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 196 KB

english, 2007

11

Imidazole moiety replacements in the 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor receptor-1 (IGF-1R) to improve cytochrome P450 profile

Upender Velaparthi, Peiying Liu, Balu Balasubramanian, Joan Carboni, Ricardo Attar, Marco Gottardis, Aixin Li, Ann Greer, Mary Zoeckler, Mark D. Wittman, Dolatrai Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 153 KB

english, 2007

12

2-(1H-Imidazol-4-yl)ethanamine and 2-(1H-pyrazol-1-yl)ethanamine side chain variants of the IGF-1R inhibitor BMS-536924

Mark G. Saulnier, David B. Frennesson, Mark D. Wittman, Kurt Zimmermann, Upender Velaparthi, David R. Langley, Charles Struzynski, Xiaopeng Sang, Joan Carboni, Aixin Li, Ann Greer, Zheng Yang, Praveen

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 161 KB

english, 2008

13

Balancing oral exposure with Cyp3A4 inhibition in benzimidazole-based IGF-IR inhibitors

Kurt Zimmermann, Mark D. Wittman, Mark G. Saulnier, Upender Velaparthi, David R. Langley, Xiaopeng Sang, David Frennesson, Joan Carboni, Aixin Li, Ann Greer, Marco Gottardis, Ricardo M. Attar, Zheng Y

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 222 KB

english, 2008

14

Insulin-like growth factor-1 receptor (IGF-1R) kinase inhibitors: SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridine-2-one

Upender Velaparthi, Mark G. Saulnier, Mark D. Wittman, Peiying Liu, David B. Frennesson, Kurt Zimmermann, Joan M. Carboni, Marco Gottardis, Aixin Li, Ann Greer, Wendy Clarke, Zheng Yang, Krista Menard

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 365 KB

english, 2010

15

Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase

Anthony J. Sampognaro, Mark D. Wittman, Joan M. Carboni, Chiehying Chang, Ann F. Greer, Warren W. Hurlburt, John S. Sack, Dolatrai M. Vyas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 529 KB

english, 2010

16

Microwave-assisted synthesis of primary amine HX salts from halides and 7 M ammonia in methanol

Mark G. Saulnier, Kurt Zimmermann, Charles P. Struzynski, Xiaopeng Sang, Upender Velaparthi, Mark Wittman, David B. Frennesson

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 241 KB

english, 2004

17

A parametric study of microencapsulation approach to the preparation of polystyrene shells

Emmanuel L. Alfonso, Shaw H. Chen, Mark D. Wittman, Semyon Papernov, David Harding

Journal:

Year:

1997

Language:

english

File:

PDF, 981 KB

english, 1997

18

Facile Synthesis of a Simplified Bicyclo[7.3.1] Esperamicin-Calicheamicin Enediyne Core

John F. Kadow, Donald J. Cook, Terrence W. Doyle, David R. Langley, Kahnie M. Pham, Dolatrai M. Vyas, Mark D. Wittman

Journal:

Year:

1994

Language:

english

File:

PDF, 1.38 MB

english, 1994

19

Stereospecific synthesis of the major human metabolite of paclitaxel

Mark D Wittman, John F Kadow, Dolatrai M Vyas

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 124 KB

english, 2000

20

Synthesis of oudehansins A and B

James Kallmerten, Mark D Wittman

Journal:

Tetrahedron Letters

Year:

1986

Language:

english

File:

PDF, 225 KB

english, 1986

21

The [2,3] Wittig rearrangement of tertiary allylic ethers. Application to the synthesis of the C12C25 subunit of zincophorin

Michael Balestra, Mark D Wittman, James Kallmerten

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 253 KB

english, 1988

22

Conjugate addition-aldol approach to the simple bicyclic-diynene core structure found in the esperamicins and calicheamicins

John F. Kadow, Min Min Tun, Dolatrai M. Vyas, Mark D. Wittman, Terrence W. Doyle

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 281 KB

english, 1992

23

Crystallographic determination of the stereochemistry of C-6,7 epoxy paclitaxel

Thomas J. Altstadt, Qi Gao, Mark D. Wittman, John F. Kadow, Dolatrai M. Vyas

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 156 KB

english, 1998

24

Stereospecific synthesis of 7-deoxy-6-hydroxy paclitaxel

Mark D. Wittman, Thomas J. Alstadt, John F. Kadow, Dolatrai M. Vyas, Kathy Johnson, Craig Fairchild, Byron Long

Journal:

Tetrahedron Letters

Year:

1999

Language:

english

File:

PDF, 193 KB

english, 1999

25

Synthesis and antitumor activity of novel paclitaxel–chlorambucil hybrids

Mark D. Wittman, John F. Kadow, Dolatrai M. Vyas, Francis L. Lee, William C. Rose, Byron H. Long, Craig Fairchild, Kathy Johnston

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 194 KB

english, 2001

26

Synthesis of metabolically blocked paclitaxel analogues

Mark D. Wittman, Thomas J. Altstadt, Craig Fairchild, Stephen Hansel, Kathy Johnston, John F. Kadow, Byron H. Long, William C. Rose, Dolatrai M. Vyas, Mu-Jen Wu, Mary E. Zoeckler

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 108 KB

english, 2001

27

The effect of propargylic substitution on the activation and aromatization of enediynes

Mark D. Wittman, John F. Kadow, Kahnie Pham, Leung Kinwa, Harold A. Mastalerz, Dolatrai M. Vyas, William C. Rose, Wyle Solomon, Nada Zein

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 289 KB

english, 1994

28

Book reviews

Mark Toma, G. Marc Choate, William C. Mitchell, Michael C. Munger, Randall G. Holcombe, Donald Wittman

Journal:

Year:

1989

Language:

english

File:

PDF, 551 KB

english, 1989

29

AN APPLICATION OF THE ANALYTIC ELEMENT METHOD IN MODELING FLORIDA EVERGLADES HYDROLOGY

Mark M. Wilsnack, Victor P. Kelson, Jack F. Wittman

Journal:

JAWRA Journal of the American Water Resources Association

Year:

2005

Language:

english

File:

PDF, 1.22 MB

english, 2005

30

Self-Interference Patterns and Their Application to Inertial-Fusion Target Characterization

Wittman, Mark D., Craxton, R. Stephen

Journal:

Year:

1999

Language:

english

File:

PDF, 510 KB

english, 1999

31

Effects of tricyclic antidepressant treatment on tyramine-O-sulfate excretion in depressed patients

Joel L. Steinberg, Paul J. Orsulak, Joachim D. Raese, Rodrick R. Gregory, Mark H. Zielinski, Patricia D. Wittman

Journal:

Journal of Affective Disorders

Year:

1993

Language:

english

File:

PDF, 643 KB

english, 1993

32

Discovery of a 1 H -Benzoimidazol-2-yl)-1 H -pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity

Wittman, Mark, Carboni, Joan, Attar, Ricardo, Balasubramanian, Balu, Balimane, Praveen, Brassil, Patrick, Beaulieu, Francis, Chang, Chiehying, Clarke, Wendy, Dell, Janet, Eummer, Jeffrey, Frennesson,

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 156 KB

english, 2005

33

Discovery of a 2,4-Disubstituted Pyrrolo[1,2- f ][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development

Wittman, Mark D., Carboni, Joan M., Yang, Zheng, Lee, Francis Y., Antman, Melissa, Attar, Ricardo, Balimane, Praveen, Chang, Chiehying, Chen, Cliff, Discenza, Lorell, Frennesson, David, Gottardis, Mar

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 1.21 MB

english, 2009

34

On the conversion of biologically interesting amines to hydroxylamines

Wittman, Mark D., Halcomb, Randall L., Danishefsky, Samuel J.

Journal:

Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 297 KB

english, 1990

35

Discovery and Evaluation of 4-(2-(4-chloro-1 H -pyrazol-1-yl)ethylamino)-3-(6-(1-(3-fluoropropyl)piperidin-4-yl)-4-methyl-1 H -benzo[ d ]imidazol-2-yl)pyridin-2(1 H )-one (BMS-695735), an Orally Efficacious Inhibitor of Insulin-like Growth Factor-1 Receptor Kinase with Broad Spectrum in Vivo Antitumor Activity

Velaparthi, Upender, Wittman, Mark, Liu, Peiying, Carboni, Joan M., Lee, Francis Y., Attar, Ricardo, Balimane, Praveen, Clarke, Wendy, Sinz, Michael W., Hurlburt, Warren, Patel, Karishma, Discenza, Lo

Journal:

Journal of Medicinal Chemistry

Year:

2008

Language:

english

File:

PDF, 205 KB

english, 2008

36

A route to glycals in the allal and gulal series: synthesis of the thiosugar of esperamicin A1

Wittman, Mark D., Halcomb, Randall L., Danishefsky, Samuel J., Golik, Jerzy, Vyas, Dolatrai

Journal:

Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 321 KB

english, 1990

37

Diastereoselective [2,3] Wittig rearrangement of tertiary allylic ethers

Wittman, Mark D., Kallmerten, James

Journal:

Journal of Organic Chemistry

Year:

1988

Language:

english

File:

PDF, 405 KB

english, 1988

38

[Annual Reports in Medicinal Chemistry] Annual Reports in Medicinal Chemistry Volume 44 Volume 44 || Chapter 14 Recent Progress in the Development of Small Molecule Inhibitors of Insulin-Like Growth Factor-1 Receptor Kinase

Wittman, Mark D.

Year:

2009

Language:

english

File:

PDF, 1.13 MB

english, 2009

39

The synthesis of the core trisaccharide of esperamicin: corroboration of the proposed structure for its rearrangement product and stabilization of the core trisaccharide domain

Halcomb, Randall L., Wittman, Mark D., Olson, Steven H., Danishefsky, Samuel J., Golik, Jerzy, Wong, Henry, Vyas, Dolatrai

Journal:

Journal of the American Chemical Society

Year:

1991

Language:

english

File:

PDF, 413 KB

english, 1991

40

Stereocontrolled synthesis of highly oxygenated acyclic systems via the enolate Claisen rearrangement of O-protected allylic glycolates

Gould, Thomas J., Balestra, Michael, Wittman, Mark D., Gary, Jill A., Rossano, Lucius T., Kallmerten, James

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 1.75 MB

english, 1987

41

Synthesis of the oudemansins, naturally occuring .beta.-methoxyacrylates from Basidomycetes

Wittman, Mark D., Kallmerten, James

Journal:

Journal of Organic Chemistry

Year:

1987

Language:

english

File:

PDF, 664 KB

english, 1987

42

Synthesis and Antitumor Activity of Novel C-7 Paclitaxel Ethers: Discovery of BMS-184476

Altstadt, Thomas J., Fairchild, Craig R., Golik, Jerzy, Johnston, Kathy A., Kadow, John F., Lee, Francis Y., Long, Byron H., Rose, William C., Vyas, Dolatrai M., Wong, Henry, Wu, Mu-Jen, Wittman, Mark

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 92 KB

english, 2001

43

SPIE Proceedings [SPIE San Diego - DL tentative - San Diego, CA (Monday 1 July 1991)] Laser Interferometry IV: Computer-Aided Interferometry - High-precision characterization of gas-filled shells using scanning Fabry-Perot interferometry

Wittman, Mark D., Malacara, Daniel, Kong, Hong-Jin, Pryputniewicz, Ryszard J.

Year:

1992

Language:

english

File:

PDF, 716 KB

english, 1992

44

A NEW CATHETER FOR PROXIMAL PULMONARY ARTERY PRESSURE MONITORING

Santora, Thomas A., Wittman, Mark, Cold, Julian, Leyerle, Beverley, Swan, H J.C., Ganz, William, Shabot, M. Michael

Journal:

Critical Care Medicine

Year:

1990

File:

PDF, 83 KB

1990

45

New method for monitoring pulmonary artery catheter location

SANTORA, THOMAS, GANZ, WILLIAM, GOLD, JULIAN, WITTMAN, MARK, LEYERLE, BEVERLEY, SWAN, H. J. C., SHABOT, M. MICHAEL

Journal:

Critical Care Medicine

Year:

1991

File:

PDF, 397 KB

1991

46

SPIE Proceedings [SPIE 1989 Intl Congress on Optical Science and Engineering - Paris, France (Monday 24 April 1989)] X-Ray Instrumentation in Medicine and Biology, Plasma Physics, Astrophysics, and Synchrotron Radiation - X-Ray Microscopy Of Living Biological Specimens Using A Laser-Plasma As An X-Ray Source

Kim, Hyo-gun, Cheng, Ping-Chin, Wittman, Mark D., Kong, Hong-Jin, Benattar, Rene

Year:

1989

Language:

english

File:

PDF, 7.06 MB

english, 1989

47

SPIE Proceedings [SPIE 1994 Symposium on Astronomical Telescopes & Instrumentation for the 21st Century - Kailua, Kona, HI (Sunday 13 March 1994)] Adaptive Optics in Astronomy - High-resolution infrared imaging utilizing a tip-tilt secondary mirror

Close, Laird M., Wittman, David M., McCarthy, Jr., Donald W., Ealey, Mark A., Merkle, Fritz

Year:

1994

Language:

english

File:

PDF, 430 KB

english, 1994

48

SPIE Proceedings [SPIE 1994 Symposium on Astronomical Telescopes & Instrumentation for the 21st Century - Kailua, Kona, HI (Sunday 13 March 1994)] Adaptive Optics in Astronomy - Preliminary closed-loop results from an adaptive optics system using a sodium resonance guide star

Lloyd-Hart, Michael, Angel, James Roger P., Jacobsen, Bruce P., Wittman, David M., McCarthy, Jr., Donald W., Kibblewhite, Edward J., Carter, Barbara, Wild, Walter J., Ealey, Mark A., Merkle, Fritz

Year:

1994

Language:

english

File:

PDF, 274 KB

english, 1994

49

SPIE Proceedings [SPIE 1993 North American Conference on Smart Structures and Materials - Albuquerque, NM (Monday 1 February 1993)] Active and Adaptive Optical Components and Systems II - Diffraction-limited K-band imaging at the Multiple Mirror Telescope with adaptive optics

Lloyd-Hart, Michael, Colucci, D'nardo, Wittman, David M., McLeod, Brian A., Ghez, A., McCarthy, Jr., Donald W., Dekany, Richard G., Angel, James Roger P., Ealey, Mark A.

Year:

1993

Language:

english

File:

PDF, 630 KB

english, 1993

50

Carbon Trading

Mark Johnson and Hannah Wittman

Journal:

Frontiers in Ecology and the Environment

Year:

2008

Language:

english

File:

PDF, 298 KB

english, 2008